Study of the electrolyte-insulator-semiconductor field-effect transistor (EISFET) with applications in biosensor design

This paper presents a comprehensive review of the ion-sensitive field-effect transistor (ISFET) and its applications in biomolecular sensing and characterization of electrochemical interfaces. An introduction to the physics of field-effect transistors is presented, followed by a study of the properties of electrolytic solutions and electrolyte interface surface effects. Full modeling of the ion-sensitive transistor is given, followed by a survey of the different uses of the ISFET in biomedical and environmental applications. Particular attention is given to the use of the ion-sensitive transistors as replacements for microarrays in DNA gene expression analysis. 2006 Published by Elsevier Ltd.